Cancer Research Articles of Interest - Hosein Kouros-Mehr

I will be posting one cancer research article per week related to cancer metastasis, immunotherapy, angiogenesis, and pathways related to cell proliferation and apoptosis.

March 21, 2014:

1.  RTEL1 -- Interesting novel target that is frequently amplified in cancers according to TCGA database (publicly available information).  This paper sheds light on its potential mechanism in cancer.

RTEL1: functions of a disease-associated helicase

 

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Trends in Cell Biology, 26 February 2014
Copyright © 2014 Elsevier Ltd All rights reserved.
10.1016/j.tcb.2014.01.004

Authors

Jean-Baptiste Vannier,Grzegorz Sarek,Simon J. BoultonSee Affiliations

• Highlights
• RTEL1 is an Fe–S helicase that controls homologous recombination by dismantling D-loop intermediates.
• RTEL1 maintains telomere integrity by disassembling T-loops and counteracting G4-DNA structures.
• RTEL1 variants strongly associate with predisposition to glioma, astrocytoma, and glioblastoma.
• Mutations in RTEL1 give rise to Hoyeraal–Hreidarsson syndrome.

Hosein Kouros-Mehr